P opular liver health supplements such as milk thistle, artichoke, vitamin C, and others are marketed with unfounded claims that they “detoxify,” “cleanse,” and “nourish” the liver.
Research suggests that although they might benefit those with existing liver disease, they don’t help those with healthy livers.
In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. When choosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist
However, factors like poor diet, alcohol consumption, medications, and environmental toxins can overburden this organ, leading to sluggish performance and a cascade of health issues.
While lifestyle changes like a nutrient-rich diet and regular exercise can help, adding the right liver health supplement can make a significant difference.
How Can You Tell a Good Liver Health Supplement from a Bad One?
Did you know that nearly 1 in 4 adults suffers from some degree of liver dysfunction? Unfortunately, many people turn to ineffective products or even scams.
The supplement industry is flooded with low-quality formulations that make bold promises but fail to deliver results.
Our team has analyzed the leading liver health products on the market, filtering out scams and subpar options to bring you the top five proven supplements for liver health. Based on our research, here’s how to distinguish top-tier supplements from the rest:
5 Must-Have Ingredients for Effective Liver Support
- Milk Thistle (Silymarin): A powerful antioxidant known to support liver cell regeneration and protect against toxin damage. Look for standardized extracts with high silymarin content.
- N-Acetyl Cysteine (NAC): This amino acid boosts glutathione production, the liver’s most potent detoxifying antioxidant.
- Artichoke Leaf Extract: Supports bile production, aiding digestion and liver detoxification. Standardized extracts ensure maximum efficacy.
- Turmeric (Curcumin): A potent anti-inflammatory that combats oxidative stress. Pair with piperine to enhance absorption.
- Dandelion Root: Known for its diuretic and liver-cleansing properties, it helps flush toxins and reduce liver congestion.
Go to 5 Overall Best Joint Supplements
Warning Signs: Avoid Wasting Money on Subpar Supplements
- Lack of Clinical Testing: Supplements without third-party clinical trials may not deliver real results. Look for pharmaceutical-grade testing standards.
- Unproven Ingredients: Avoid products boasting overly complex ingredient lists or relying on herbs with minimal research. Fewer, proven ingredients ensure quality.
- Inflated Claims: Be cautious of promises like “instant detox” or “cures fatty liver.” A legitimate supplement supports gradual, natural healing—not miracles.
When Can You Expect Results?
While some ingredients provide fast relief, improving liver function and detoxification takes time. Based on research, here’s what you can expect:
Consistency is key—taking your supplement daily for at least two months ensures long-term benefits.
To separate the best from the rest, focus on these proven ingredients:
The Top 5 Liver Health Supplements of 2025
Based on safety, effectiveness, and real user results, here are the top-performing liver health supplements of the year.
We also provide a detailed side-by-side comparison of these supplements, highlighting their strengths and weaknesses.
Below, we break down our rankings and feature detailed reviews of the 5 best liver health supplements we analyzed, beginning with our top pick.
Best Overall: ⭐⭐⭐⭐⭐ (9.8/10)
- Clinically tested in a placebo-controlled trial by Princeton Consumer Research.
- Contains all 5 must-have ingredients for liver support.
- 90% of participants reported reduced bloating within two weeks*
- Free from fillers and artificial additives
- Vegetarian, non-GMO, and gluten-free
- Made in the USA
Liver Flow plus by Nutreance earned our #1 ranking because it is the only liver health supplement that meets every one of our strict criteria.
It includes all five essential ingredients for liver health—N-Acetyl Cysteine (NAC), Milk Thistle (standardized to 80% silymarin), Choline Bitartrate, Dandelion Root, and Artichoke Leaf—while being free from additives.
For the best prices and shipping, we recommend purchasing directly from Liver Flow Plus’s official website, where additional discounts are available. Click here to visit the product website.
Rating #2: ⭐⭐⭐⭐☆ (9.7/10)
- Contains 4 out of 5 must-have ingredients
- Low-dose, high-efficiency formula
- Supports liver detoxification
- Available in 2 sizes
- 90-Day Money-Back Guarantee.
- No artificial additives
- Enhances bile production for better digestion
Why Liver Renew #2: It’s a strong contender, featuring milk thistle, choline, dandelion root, and artichoke leaf. However, its lack of N-acetyl cysteine and lower silymarin content make it less comprehensive than Liver Flow Plus.
For the best prices and shipping, we recommend purchasing directly from Liver Renew’s official website, where additional discounts and products are available. Click here to visit the product website.
Rating #3: ⭐⭐⭐☆☆ (9.5/10)
- Includes 3 core ingredients: N-acetyl cysteine, silymarin, and artichoke leaf.
- Detoxify and Restore healthy liver
- 90-Day Money-Back Guarantee.
- Free of artificial additives.
- Highly praised by customers and supported by excellent service.
- Vegan, non-GMO, and gluten-free
Why LivCARE Ranked #3: LivCare by Ortho Molecular Products provides effective liver support with a strong cast of ingredients that features 4 of the primary components that we look for in a quality liver supplement: milk thistle, choline bitartrate, dandelion root, and artichoke leaf.
Verdict: For the best prices and shipping, we recommend purchasing directly from Liver Renew’s official website, where additional discounts and products are available. Click here to visit the product website.
Rating #4: ⭐⭐⭐☆☆ (8.7/10)
- Contains 3 out of 5 must-have ingredients
- Features N-acetyl cysteine and milk thistle.
- 60-Day Money-Back Guarantee.
- Vegetarian, non-GMO, and gluten-free
- Made in the USA
- ❌ Does not contain choline or dandelion
- ❌ Slightly larger than average size capsule
Rating: ⭐⭐⭐☆☆ (8.7/10)
Why Urgent Liver 911 Ranked #4: Unfortunately, Urgent Liver 911 does not contain choline or dandelion root, both of which are critical to help flush harmful toxins and fats out of the liver. It also has not been evaluated for efficacy in a clinical study.
Verdict: Contains high doses of vitamins and minerals that are likely to conflict with a daily multivitamin. Click here to visit the product website.
Rating #5: ⭐⭐☆☆☆ (8.5/10)
- Contains 2 out of 5 must-have ingredients
- No artificial additives
- Non-GMO and gluten-free
- ❌ No clinical study
- ❌ Does not contain N-acetyl cysteine, choline, or dandelion
- ❌ Contains some ingredients without sufficient evidence of efficacy
Why Triple liver Health Ranked #5: Limited effectiveness. Does not provide minimum effective doses of some ingredients. This product is also unsuitable for vegetarians due to its ox bile content.
Triple Liver Health includes two powerful detoxifiers—N-acetyl cysteine and milk thistle. However, its lack of choline, dandelion root, and artichoke reduces its overall effectiveness. (1) The milk thistle is standardized to 30% silybins, a key flavonoid complex within silymarin, ensuring a focus on its most active components.
Verdict: A basic option that lacks comprehensive healthy liver support. Click here to visit the product website.
Summary
The liver is a large organ that is involved in hundreds of bodily processes. Certain types of liver disease may hinder some of these processes and negatively impact overall health.
Scientific evidence shows that some supplements for liver health may be helpful, especially when liver disease is present. However, little research supports the use of supplements in people with healthy livers.
References
Havelin, J., & King, T. (2018). Vitamin D supplementation in older adults: A systematic review and meta-analysis. Current Osteoporosis Reports, 16(6), 763-771.
Lugo, J. P., Saiyed, Z. M., Lau, F. C., Molina, J. P., Pakdaman, M. N., Shamie, A. N., & Udani, J. K. (2013). Vitamin D supplementation and physical performance in older adults: A systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 10(1), 48.
Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). The effect of vitamin D supplementation on cognitive function in older adults: A meta-analysis of randomized controlled trials. BMC Complementary Medicine and Therapies, 20(1), 225.
Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Vitamin D and its analogs: Modulation of the immune system. Nutrients, 9(3), 290.
Shep, D., Khanwelkar, C., Gade, P., & Karad, S. (2019). Effect of vitamin D supplementation on bone mineral density and biochemical markers in postmenopausal women: A randomized controlled trial. Trials, 20(1), 214.
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. (1998). Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Medica, 64(4), 353-356.
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